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KMID : 0624620170500100504
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BMB Reports
2017 Volume.50 No. 10 p.504 ~ p.509
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The anti-microbial peptide SR-0379 stimulates human endothelial progenitor cell-mediated repair of peripheral artery diseases
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Lee Tae-Wook
Heo Soon-Chul
Kwon Yang-Woo
Park Gyu-Tae
Yoon Jung-Won
Kim Seung-Chul
Jang Il-Ho
Kim Jae-Ho
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Abstract
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Ischemia is a serious disease, characterized by an inadequate blood supply to an organ or part of the body. In the present study, we evaluated the effects of the anti-microbial peptide SR-0379 on the stem cell-mediated therapy of ischemic diseases. The migratory and tube-forming abilities of human endothelial progenitor cells (EPCs) were enhanced by treatment with SR-0379 in vitro. Intramuscular administration of SR-0379 into a murine ischemic hindlimb significantly enhanced blood perfusion, decreased tissue necrosis, and increased the number of blood vessels in the ischemic muscle. Moreover, co-administration of SR-0379 with EPCs stimulated blood perfusion in an ischemic hindlimb more than intramuscular injection with either SR-0379 or EPCs alone. This enhanced blood perfusion was accompanied by a significant increase in the number of CD31- and α-SMA-positive blood vessels in ischemic hindlimb. These results suggest that SR-0379 is a potential drug candidate for potentiating EPC-mediated therapy of ischemic diseases.
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KEYWORD
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Angiogenesis, Endothelial progenitor cells, Hindlimb ischemia, Peripheral artery diseases, SR-0379
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